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An Asymmetric Synthesis of Both Enantiomers of the Indole Alkaloid Deplancheine

โœ Scribed by Allin, Steven M.; Thomas, Christopher I.; Doyle, Kevin; Elsegood, Mark R. J.


Book ID
120927503
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
89 KB
Volume
70
Category
Article
ISSN
0022-3263

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The asymmetric synthesis of both enantio
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The asymmetric synthesis of both enantiomers of the racemic NMDA antagonist eliprodil was accom lished in a novel application of Shsrpless' asymmetric diiydroxylation (AD) methodology. A drf erence in neuroprotective activity was noted for the enantiomers in an in viva \*P model of rat focal cerebra