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An asymmetric intramolecular alkylation to form a bicyclo[3.1.0]hexanone derivative

✍ Scribed by Hamon, David P. G.; Shirley, Neil J.


Book ID
120079496
Publisher
The Royal Society of Chemistry
Year
1988
Tongue
English
Weight
189 KB
Volume
6
Category
Article
ISSN
0022-4936

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πŸ“œ SIMILAR VOLUMES


Novel asymmetric synthesis of a bicyclo[
✍ Eric D. Moher πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 192 KB

The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are