Novel asymmetric synthesis of a bicyclo[
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Eric D. Moher
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Article
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1996
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Elsevier Science
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French
β 192 KB
The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are