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Novel asymmetric synthesis of a bicyclo[3.1.0]hexane derivative by an efficient retro-diels-alder strategy

✍ Scribed by Eric D. Moher

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 192 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02025-4

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✦ Synopsis

The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are described.

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