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A novel and efficient synthetic approach to polyfunctional bicyclo[3.1.0]hexane derivatives

✍ Scribed by Miguel Díaz; Rosa M. Ortuño


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
210 KB
Volume
6
Category
Article
ISSN
0957-4166

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Novel asymmetric synthesis of a bicyclo[
✍ Eric D. Moher 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 192 KB

The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are