Novel asymmetric synthesis of a bicyclo[
✍
Eric D. Moher
📂
Article
📅
1996
🏛
Elsevier Science
🌐
French
⚖ 192 KB
The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are