## N-iodosuccinimide (ND) in the presence of an organic acid was found to be effective for the activation of fully acylated thioglycosides leading to J&trans linked esters. On the other hand, NIS together with a catalytic amount of tri#luoromethanesu&onic acid proved to be very convenient for the ra
An approach towards the synthesis of 1,2-trans glycosyl phosphates via iodonium ion assisted activation of thioglycosides
โ Scribed by G.H. Veeneman; H.J.G. Broxterman; G.A.van der Marel; J.H.van Boom
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 296 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Disarmed glycosyl trichloroacetimidates can be activated by Yb(OTf) 3 in the synthesis of 1,2-trans glycosides involving primary and secondary acceptors. Concurrent formation of orthoester side products can be avoided by the use of alkoxycarbonyl groups for the protection of the donor 2-hydroxyl.
## Abstract The nonโterminal glycosyl donor, ethyl 2,3โdiโ__O__โbenzoylโ5โ__O__โ(chloroacetyl)โ6โ__O__โpivaloylโ1โthioโฮฑโDโgalactofuranoside, could be used, with the promoter __N__โiodosuccinimide and catalytic trifluoromethanesulfonic acid, for the preparation of ฮฒโDโGal__f__โ(1โ5)โฮฒโDโGal__f__โ(1