An approach to the tremulane skeleton: Synthesis of (±)-8a-epi-tremulenolide B
✍ Scribed by Thorsten Habeck; Christian Wolff; Werner Tochtermann
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 166 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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Methyl 2,6-di-I-acetyl-6-epia-&-purpurosaminide B (11) was synthesized from L-alanine by an eleven-step reaction sequence. Eu(fod)a-mediated high-pressure (4t2)cycloaddition of 1-methoxybuta-1,3-diene (2) to a-amino aldehyde 3, easily available from Galanine (A), is the key step in the synthetic seq
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