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Amyloid β-Protein25-35Increases Cellular APP and Inhibits the Secretion of APPs in Human Extraneuronal Cells

✍ Scribed by T.L. Schmitt; E. Steiner; K. Trieb; B. Grubeck-Loebenstein

Book ID: 115602718
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 323 KB
Volume: 234
Category: Article
ISSN: 0014-4827
DOI: 10.1006/excr.1997.3606

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st