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Increased β-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation

✍ Scribed by Janet A. Johnston; Richard F. Cowburn; Svante Norgren; Birgitta Wiehager; Nikolaos Venizelos; Bengt Winblad; Carmen Vigo-Pelfrey; Dale Schenk; Lars Lannfelt; Cora O'Neill


Book ID
115929576
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
777 KB
Volume
354
Category
Article
ISSN
0014-5793

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison