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Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP

✍ Scribed by Sergio Zarazúa; Susanne Bürger; Juan M. Delgado; Maria E. Jiménez-Capdeville; Reinhard Schliebs


Book ID
116552413
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
450 KB
Volume
29
Category
Article
ISSN
0736-5748

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st