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Amplification of the met gene in glioma

✍ Scribed by Ulrike Fischer; Hans-W. Müller; Hans-P. Sattler; Klaus D. Zang; Eckart Meese; Klaus Feiden

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
738 KB
Volume
12
Category
Article
ISSN
1045-2257

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✦ Synopsis

We have previously reported the finding of MET amplification linked to double minutes (dmins) in a human glioblastoma (TX3095). Because dmins are found in approximately 50% of glioblastomas, 18 gliomas were analyzed for MET amplification. Three grade IV glioblastomas and one grade II astrocytoma showed amplification. W e could also localize the MET amplicon to dmins in glioblastorna TX3095 by fluorescence in situ hybridization. Genes Chromosorn Cancer 1263-65 (1995).

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