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Amplification of SKI Is a Prognostic Marker in Early Colorectal Cancer

✍ Scribed by Buess, Martin; Terracciano, Luigi; Reuter, Jürgen; Ballabeni, Pierluigi; Boulay, Jean-Louis; Laffer, Urban; Metzger, Urs; Herrmann, Richard; Rochlitz, Christoph F.


Book ID
123292466
Publisher
Neoplasia Press
Year
2004
Tongue
English
Weight
169 KB
Volume
6
Category
Article
ISSN
1522-8002

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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFβ signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre