𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Amplification of c-ras-ki oncogene in human ovarian tumours

✍ Scribed by E. M. Boltz; R. F. Kefford; J. A. Leary; C. R. Houghton; M. L. Friedlander

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
509 KB
Volume
43
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Amplification of the c-ras-Ki oncogene has been the most consistent finding reported in studies on oncogene activation in ovarian cancer, but for the most part the studies have been small and the results conflicting. In order to determine whether amplification occurred de novo in primary tumours or was associated with tumour progression and metastasis, 8 I tumour samples from different sites in 26 patients with ovarian tumours and 7 xenografted ovarian tumour cell lines were assayed. Amplification of c-ras-Ki occurred infrequently and was apparent in a single metastatic site in a patient with poorly differentiated serous cystadenocarcinoma of the ovary. Ten-fold amplification of the c-ras-Ki oncogene was also evident in a benign ovarian fibroma. Amplification of the c-ras-Ki oncogene is rare in ovarian tumours and does not appear to play a fundamental role in tumour development or progression.

πŸ“œ SIMILAR VOLUMES

Amplification of c-myc oncogene and abse
Amplification of c-myc oncogene and absence of c-Ha-ras point mutation in human bone sarcoma
✍ Dr. Carlos Barrios; Javier S. Castresana; Juan Ruiz; Andris Kreicbergs πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 733 KB

## Abstract The genomic organization of four oncogenes, __c__‐__myc__, __c__‐__myb__, __c__‐__Ha__‐__ras__, and __v__‐__fms__, was analyzed in 21 patients with malignant bone tumors. Amplification of the __c__‐__myc__ proto‐oncogene without rearrangement was the sole abnormality detected in four tu

Image analysis in quantitative PCR. An a
Image analysis in quantitative PCR. An application for the measurement of c-erbB-2 oncogene amplification in DNA from human tumours
✍ Orlando, C. ;Sestini, R. ;Zentilin, L. ;Gelmini, S. ;Pinzani, P. ;Giacca, M. ;Pa πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons βš– 511 KB

We present a n application o f image analysis for the direct quantification o f PCR products after gel electrophoresis and ethidium bromide staining o f DNA. This procedure has been applied t o the development of a n assay based on competitive PCR for the measurement o f the degree o f amplification

High frequency of ki-ras amplification a
High frequency of ki-ras amplification and p53 gene mutations in adenocarcinomas of the human esophagus
✍ Corinne Galiana; Jean-Claude Lozano; Brigitte Bancel; Hisayoshi Nakazawa; Hirosh πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 835 KB

## Abstract Mutated __ras__ genes have been found to be conspicuously absent from primary tumors of the esophagus, although high expression of ras p21 oncoprotein in some esophageal squamous cell carcinomas and mutations of the Ki‐ and Ha‐__ras__ genes in esophageal carcinoma cell lines have been r

Cholangiocarcinomas in japanese and thai
Cholangiocarcinomas in japanese and thai patients: Difference in etiology and incidence of point mutation of the c-KI-ras proto-oncogene
✍ Hitoshi Tsuda; Soisungwan Satarug; Vajarabhongsa Bhudhisawasdi; Toshimasa Kihana πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 395 KB

## Abstract Point‐mutational activation of the c‐Ki‐__ras__ proto‐oncogene has been shown to be rare in human hepatocellular carcinoma, the most common primary liver cancer and one usually associated with chronic viral infection. To reveal the association of c‐Ki‐__ras__ activation with cholangioca