Amplification of c-myc and c-erbB-2 proto-oncogenes in human solid tumors: Frequency and clinical significance

✍ Scribed by M. Gutman; Y. Ravia; D. Assaf; T. Yamamoto; R. Rozin; Y. Shiloh

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: French
• Weight: 604 KB
• Volume: 44
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910440509

✦ Synopsis

Molecular probes for cellular proto-oncogenes have recently been extensively used in order to search for functional and structural alterations in tumor tissues. Variable, and sometimes contradictory, results have been obtained regarding the frequency and clinical significance of amplification of the c-myc and c-erbB-2 proto-uncogenes in different series of human solid tumors. We addressed this question by performing Southern blotting analysis on 131 primary adult solid tumors of various tissues and 5 m e -of unknown origin, using molecular probes for both genes. Amplification of c-myc was found in 5 of the primary tumors, and amplification of c-&-2 in 5 others. In 2 tumors of the latter grou the c-erM-2 gene was also rearranged. The distribution J'hese 10 tumors with regard to clinical stage and course of the disease did not point to an association between the amplification events and specific stage or prognosis. We concluded that, in this series, the amplification of both proto-oncogenes was occasional and was not a prognostic marker.

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