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Amphotericin B : Synthesis of Its Aglycone (Amphoteronolide B) and Degradation

✍ Scribed by SATORU MASAMUNE


Book ID
119862122
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
441 KB
Volume
544
Category
Article
ISSN
0890-6564

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πŸ“œ SIMILAR VOLUMES


Synthesis of amphotericin B. 2. fragment
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Fragment C-D, the C(Zl)-C(37) unit of the aglycone of amphotericin B, has been synthesized. Amphotericin B (l), a 38-membered polyenemacrolide antibiotic,I has been one of our synthetic target molecules. This molecule is retrosynthetically dissected into four fragments A, B, C, and D as indicated, a

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The C15-C27 segment 2 of the aglycone ,$ of venturicidins A and B was synthesized and then total synthesis of 3 was accomplished via intramolecular Wittig-Horner reaction of the ester from 2 and the previously synthesized Cl-Cl4 segment 1. In the preceding paper, the synthesis of the Cl-Cl4 segment