Amphotericin B : Synthesis of Its Aglycone (Amphoteronolide B) and Degradation
β Scribed by SATORU MASAMUNE
- Book ID
- 119862122
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 441 KB
- Volume
- 544
- Category
- Article
- ISSN
- 0890-6564
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π SIMILAR VOLUMES
Fragment C-D, the C(Zl)-C(37) unit of the aglycone of amphotericin B, has been synthesized. Amphotericin B (l), a 38-membered polyenemacrolide antibiotic,I has been one of our synthetic target molecules. This molecule is retrosynthetically dissected into four fragments A, B, C, and D as indicated, a
The C15-C27 segment 2 of the aglycone ,$ of venturicidins A and B was synthesized and then total synthesis of 3 was accomplished via intramolecular Wittig-Horner reaction of the ester from 2 and the previously synthesized Cl-Cl4 segment 1. In the preceding paper, the synthesis of the Cl-Cl4 segment