Synthesis of amphotericin B. 2. fragment
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Diane Boschelli; Toshiro Takemasa; Yasuhiro Nishitani; Satoru Masamune
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Article
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1985
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Elsevier Science
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French
β 257 KB
Fragment C-D, the C(Zl)-C(37) unit of the aglycone of amphotericin B, has been synthesized. Amphotericin B (l), a 38-membered polyenemacrolide antibiotic,I has been one of our synthetic target molecules. This molecule is retrosynthetically dissected into four fragments A, B, C, and D as indicated, a