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Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line

✍ Scribed by Nicola Normanno; Mouna P. Selvam; Caterina Bianco; Vincenzo Damiano; Ernesto de Angelis; Michele Grassi; Gabriella Magliulo; Giampaolo Tortora; David S. Salomon; Fortunato Ciardiello

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 604 KB
Volume: 62
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910620619

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✦ Synopsis

Amphiregulin (AR) is a secreted heparin-binding growth factor that is structurally and functionally related to epidermal growth factor (EGF) and transforming growth factor a (TGFa). CEO cells are from a human colon cancer cell line that expresses high levels of AR protein and mRNA. To assess the role of AR in colon-cancer cell proliferation and transformation, 2 different anti-sense 20-mer phosphorothioate oligodeoxynucleotides (AR AS-I and AR AS-2 S-oligos) complementary to the 5 ' sequence of AR rnRNA were synthesized. Both AR AS

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