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Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line

✍ Scribed by Gustavo Baldassarre; Caterina Bianco; Giampaolo Tortora; Angela Ruggiero; Mark Moasser; Ethan Dmitrovsky; A. Raffaele Bianco; Fortunato Ciardiello

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 755 KB
Volume: 66
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960516)66:4<538::aid-ijc19>3.0.co;2-3

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## Abstract Transforming growth factor α (TGFα) is a growth factor produced by colon cancer cells which may function as an autocrine growth regulator. Therefore, the proliferation and transformation of colon cancer cells might be attenuated by blocking the production of endogenous TGFα. GEO cells,