## Abstract It is known that dibutyryl cyclic AMP (dbcAMP) and theophylline inhibit the spontaneous maturation of isolated mouse oocytes. The present study demonstrates that dbcAMP (0.01 β 1.0 mM) as well as cyclic AMP (cAMP, 10 mM) and a phosphodiesterase inhibitor (IBMX, 0.01 β 1.0 mM) prevent sp
Amphibian Oocyte Maturation and Protein Synthesis: Related Inhibition by Cyclic AMP, Theophylline, and Papaverine
β Scribed by Rodrigo Bravo, Carlos Otero, Catherine C. Allende and Jorge E. Allende
- Book ID
- 123654981
- Publisher
- National Academy of Sciences
- Year
- 1978
- Tongue
- English
- Weight
- 785 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/67975
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Testosterone, progesterone, and estradiol-17P each inhibit CAMP phosphodiesterase activity of mouse oocyte extracts in a concentrationdependent manner. This finding provides an explanation for the inhibitory effect of steroid hormones on germinal vesicle breakdown (GVBD) of mouse oocytes in vitro. F
## Abstract Mouse oocytes arrested in dictyate of the first meiotic prophase by dibutyryl cyclic AMP accumulated exogenous valine at the same rate as oocytes undergoing meiotic maturation. The apparent rate of protein synthesis and the spectrum of proteins synthesized were not significantly affecte