✦ LIBER ✦
Inhibition of mouse oocyte cyclic AMP phosphodiesterase by steroid hormones: A possible mechanism for steroid hormone inhibition of oocyte maturation
✍ Scribed by Kaji, Eugene ;Bornslaeger, Elayne A. ;Schultz, Richard M.
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 459 KB
- Volume
- 243
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Testosterone, progesterone, and estradiol-17P each inhibit CAMP phosphodiesterase activity of mouse oocyte extracts in a concentrationdependent manner. This finding provides an explanation for the inhibitory effect of steroid hormones on germinal vesicle breakdown (GVBD) of mouse oocytes in vitro. Furthermore, it raises the possibility that steroid hormones present in follicular fluid participate in maintaining meiotic arrest in vivo by acting in a nonclassical manner.