AMP-activated protein kinase regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts: Involvement of mitogen-activated protein kinases
β Scribed by Kenji Kato; Takanobu Otsuka; Akira Kondo; Rie Matsushima-Nishiwaki; Hideo Natsume; Osamu Kozawa; Haruhiko Tokuda
- Book ID
- 116720108
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 406 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0024-3205
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## Abstract It has been reported that plateletβderived growth factor (PDGF)βBB stimulates the synthesis of interleukin (IL)β6 in osteoblasts. In the present study, we investigated whether the phosphatidylinositol 3βkinase (PI3K)/Akt is involved in the PDGFβBBβinduced ILβ6 synthesis in osteoblastβli
We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 c