## Abstract Inflammatory cytokines are well known to play crucial roles in the pathogenesis of rheumatoid arthritis. Among them, interleukin (IL)โ17 is a cytokine that is mainly synthesized by activated T cells and its receptors are present in osteoblasts. The synthesis of ILโ6, known to stimulate
โฆ LIBER โฆ
The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts
โ Scribed by H.J Chae; S.W Chae; H.Y Chin; B.G Bang; S.B Cho; K.S Han; S.C Kim; K.C Tae; K.H Lee; D.E Kim; M.K Im; S.J Lee; J.Y Chang; Y.M Lee; H.M Kim; H.H Kim; Z.H Lee; H.R Kim
- Book ID
- 117807074
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 386 KB
- Volume
- 28
- Category
- Article
- ISSN
- 8756-3282
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We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 c
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