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Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts

✍ Scribed by Osamu Kozawa; Haruhiko Tokuda; Hiroyuki Matsuno; Toshihiko Uematsu

Book ID: 117108448
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 332 KB
Volume: 418
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(97)01366-5

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We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 c