p42/p44 Mitogen-Activated Protein Kinase Activation Is Involved in Prostaglandin F2α-Induced Interleukin-6 Synthesis in Osteoblasts
✍ Scribed by Haruhiko Tokuda; Osamu Kozawa; Atsushi Harada; Toshihiko Uematsu
- Book ID
- 114284176
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 236 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0898-6568
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We previously reported that prostaglandin F 2␣ (PGF 2␣ ) activates both phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells and then induces the activation of protein kinase C (PKC). In this study, we investigated the eff
We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 c