Ammonia is the principal neurotoxin implicated in the pathogenesis of hepatic encephalopathy, and astrocytes are the neural cells predominantly affected in this condition. Astrocyte swelling (cytotoxic edema) represents a critical component of the brain edema in acute form of hepatic encephalopathy
Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake
โ Scribed by K.S. Panickar; A.R. Jayakumar; K.V. Rama Rao; M.D. Norenberg
- Book ID
- 116765244
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 413 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0197-0186
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Astroglial swelling occurs in acute hyperammonemic states, including acute hepatic encephalopathy. In these conditions, the peripheral-type benzodiazepine receptor (PBR), a receptor associated with neurosteroidogenesis, is up-regulated. This study examined the potential involvement of PBRs and neuro
The effects of glutamate and its agonists and antagonists on the swelling of primary astrocytes were studied. Glutamate (Glu), aspartate (Asp), homocysteate (HCA), and quisqualate (Quis) at 1 mM concentration caused a significant increase in astrocytic swelling as measured by the 3-0-methyl-['4C]-gl
Cytotoxic brain edema, usually a consequence of astrocyte swelling, is an important complication of stroke, traumatic brain injury, hepatic encephalopathy, and other neurological disorders. Although mechanisms underlying astrocyte swelling are not fully understood, oxidative stress (OS) has generall