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745 BENEFICIAL EFFECT OF N-ACETYLCYSTEINE AND GLUTATHIONE ON AMMONIA-INDUCED GLUTAMATE ACCUMULATION IN ASTROCYTE CELL CULTURE

✍ Scribed by D. Donnini; L. Domenis; D. De Silvestri; D. Cappello; A. Dibenedetto; A. Carnelutti; L. Sechi; G. Soardo

Book ID: 117377752
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 64 KB
Volume: 50
Category: Article
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(09)60747-9

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## Abstract Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver disease. While the pathogenesis of HE is unclear, elevated blood and brain ammonia levels are believed to be major etiological factors, and astrocytes appear to be the primary target of its to