✦ LIBER ✦

Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53

✍ Scribed by Mann, Kristine; Hainaut, Pierre

Book ID: 110069617
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 339 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208563

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Differential gene expression in mouse ma

Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53

✍ Cui, Xian-Shu; Donehower, Lawrence A 📂 Article 📅 2000 🏛 Nature Publishing Group 🌐 English ⚖ 415 KB

Restoration of wild-type conformation an

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53V272M) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1

✍ Sophie North; Olivier Pluquet; Daniela Maurici; Fatiha El Ghissassi; Pierre Hain 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres

Dependence of induction of osteocalcin g

Dependence of induction of osteocalcin gene expression on the presence of wild-type p53 in a murine osteosarcoma cell line

✍ Nalini Chandar; Phil Campbell; Josef Novak; Martin Smith; Martin Smith 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 704 KB

## Abstract The __p53__ gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. A __p53__‐null murine osteosarcoma cell line F6 was transfected with either a wild‐type or a mutant __p53__ gene. Stably transfected cell lines were obtained, and their d

Differential involvement of the CD95 (Fa

Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells

✍ Fukazawa, Takuya; Fujiwara, Toshiyoshi; Morimoto, Yoshinori; Shao, Jianghua; Nis 📂 Article 📅 1999 🏛 Nature Publishing Group 🌐 English ⚖ 553 KB

Introduction of wild-type p53 gene downr

Introduction of wild-type p53 gene downregulates the expression of H-ras gene and suppresses the growth of bladder cancer cells

✍ Li, M. ;Gu, F. L. ;Li, W. B. ;Song, Y. S. ;Zhou, A. R. ;Guo, Y. L. 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 460 KB

Retroviral vectors were used to introduce the wild-type p53 gene into human bladder cancer cell lines BIU-87 and EJ, which express endogenous wt-p53 gene and have a mutation in H-ras gene. The expression of the exogenous wt-p53 gene in cells suppresses the growth of the bladder cancer cells in stand

Nonhomologous end-joining of site-specif

Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53

✍ Dahm-Daphi, Jochen; Hubbe, Petra; Horvath, Fruzsina; El-Awady, Raafat A; Bouffar 📂 Article 📅 2005 🏛 Nature Publishing Group 🌐 English ⚖ 298 KB