Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53
โ Scribed by Cui, Xian-Shu; Donehower, Lawrence A
- Book ID
- 110064305
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 415 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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The cytotoxicity of Doxorubicin and cis-dichloro-diammineplatinum (DDP) was evaluated in clones, obtained from a human ovarian cancer cell line transfected with a ternperaturesensitive p53 mutant, which express mutant p53 at 37ยฐC and wild-type-like p53 at 32ยฐC. DDP was equally active in cells not ex