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Amino acid cluster formation studied by electrospray ionization mass spectrometry

✍ Scribed by Péter Nemes; Gitta Schlosser; Károly Vékey

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
189 KB
Volume
40
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The association properties of natural and non‐natural amino acids were studied in detail using electrospray ionization mass spectrometry. The results show a highly diverse cluster formation behavior of amino acids. There are differences regarding the degree of clustering (average cluster size), the presence or absence of one or several ‘magic’ clusters of special stability and the influence of chirality on cluster stability. Cluster formation does not show a good correlation with simple physico‐chemical properties (such as solubility), indicating that it is a specific process and not only a simple aggregation during evaporation/ionization. A systematic study of cluster formation of serine derivatives reveals that all functional groups play a prominent role in the binding of the magic octamer. The results support the idea of the zwitterionic character of the octamer. Electrospray ionization of the side‐chain acetylated serine shows the formation of a very stable tetramer with a strong preference for homochirality. The results suggest that Ser~8~ is made up of two tetramer subunits, held together by hydrogen bonds of the side‐chain. Copyright © 2004 John Wiley & Sons, Ltd.

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