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Amino acid based bioanalogous polymers. Novel regular poly(ester urethane)s and poly(ester urea)s based on bis(L-phenylalanine) α,ω-alkylene diesters

✍ Scribed by Tamara Kartvelishvili; George Tsitlanadze; Lamara Edilashvili; Nona Japaridze; Ramaz Katsarava

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 517 KB
Volume: 198
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.1997.021980620

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✦ Synopsis

Abstract

Novel biodegradable regular poly(ester urethane)s 2 (η~red~ ≤ 0,62 dL/g) were synthesized for the first time by polycondensation of di‐p‐toluenesulfonic acid salts of bis(phenylalanine) α,ω‐alkylene diesters 1 with di‐p‐nitrophenyl trimethylenedicarbonate (4) under mild conditions in organic solvents in the presence of triethylamine as acid acceptor. The first synthesis of homopoly(ester urea)s 3 (η~red~ ≤ 0,33 dL/g) was carried out by polycondensation of 1 with di‐p‐nitrophenyl carbonate (5) under the same conditions. Preliminary in vitro evaluation of specific and nonspecific hydrolysis of the polymers obtained has been brought about using potentiometric titration.

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