𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Amino acid based bioanalogous polymers. Synthesis of novel poly(urethane amide)s based on N,N′-(trimethylenedioxydicarbonyl)bis(phenylalanine)

✍ Scribed by Tamara Kartvelishvili; Akaki Kvintradze; Ramaz Katsarava

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
409 KB
Volume
197
Category
Article
ISSN
1022-1352

No coin nor oath required. For personal study only.

✦ Synopsis

The feasibility of synthesizing high-molecular-weight amino acid based bioanalogous polymers (AABBPs)-poly(urethane amide)s (PUA) -via polycondensation (PC) of dip-nitrophenyl ester of N,~-(trimethylenedioxydicarbonyl)bis(L-phenylalanine) (3) with diamines or their derivatives under mild conditions in organic solvents was studied for the first time. A regular PUA (q,,,, = 1,53 dL/g) was obtained by PC of 3 with hexamethylenediamine. A dipeptide (Phe-Phe) containing regular poly(ester urethane amide) (q,,,, = 0,58 dL/g) was synthesized by PC of 3 with p-toluenesulfonic acid salt of bis(L-phenylalanine) 1,4-butylene diester. A tripeptide (Phe-Lys-Phe) containing PUA (qred = 0,38 dL/g) with pendent ester groups was prepared via PC of 3 with N,N-bis(trimethylsily1)-L-lysine methyl ester. These novel AABBPs which may be considered as structural analogs of AB type bioanalogous polymers -conventional poly(amino acids) are of interest in enzymology, immunology, pharmacology, and biotechnology (as materials for biomedical applications).

📜 SIMILAR VOLUMES

Amino acid-based bioanalogous polymers.
Amino acid-based bioanalogous polymers. Synthesis, and study of regular poly(ester amide)s based on bis(α-amino acid) α,ω-alkylene diesters, and aliphatic dicarboxylic acids
✍ R. Katsarava; V. Beridze; N. Arabuli; D. Kharadze; C. C. Chu; C. Y. Won 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 2 views

The purpose of this research was to synthesize new regular poly(ester amide)s (PEAs) consisting of nontoxic building blocks like hydrophobic ␣-amino acids, ␣,-diols, and aliphatic dicarboxylic acids, and to examine the effects of the structure of these building block components on some physico-chemi

Synthesis and characterization of novel
Synthesis and characterization of novel poly(amide imide)s based on bis(p-amidobenzoic acid)-n-trimellitylimido-L-leucine
✍ Shadpour E. Mallakpour; Abdol-Reza Hajipour; Ramin Vahabi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 2 views

## Abstract __N__‐Trimellitylimido‐L‐leucine was reacted with thionyl chloride, and __N__‐trimellitylimido‐L‐leucine diacid chloride was obtained in a quantitative yield. The reaction of this diacid chloride with __p__‐aminobenzoic acid was performed in dry tetrahydrofuran, and bis(__p__‐amidobenzo

Heterochain polymers based on natural am
Heterochain polymers based on natural amino acids. Synthesis and enzymatic hydrolysis of regular poly(ester amide)s based on bis(L-phenylalanine) α,ω-alkylene diesters and adipic acid
✍ Natia Arabuli; George Tsitlanadze; Lamara Edilashvili; Darejan Kharadze; Tsisana 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB

## Abstract Novel biodegradable regular poly(ester amide)s were synthesized by polycondensation of __p__‐toluenesulfonic acid salts of bis(phenylalanine) α,ω‐alkylene diesters (1) with bis(__p__‐nitrophenyl) adipate under mild conditions in organic solvents in the presence of triethyl amine as acid

New optically active poly(amide-imide)s
New optically active poly(amide-imide)s based on N,N′-(pyromellitoyl)-bis-L-amino acid and 1,3-bis(4-aminophenoxy) propane: Synthesis and characterization
✍ Khalil Faghihi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB 👁 2 views

## Abstract Five new poly(amide‐imide)s **8a–e** were synthesized through the direct polycondensation reaction of five chiral __N__,__N__′‐(pyromellitoyl)‐bis‐L‐amino acids **3a–e** with 1,3‐bis(4‐aminophenoxy) propane **7** in a medium consisting of __N__‐methyl‐2‐pyrrolidone, triphenyl phosfite,

Synthesis and properties of novel aromat
Synthesis and properties of novel aromatic polyhydrazides and poly(amide–hydrazide)s based on the bis(ether benzoic acid)s from hydroquinone and substituted hydroquinones
✍ Sheng-Huei Hsiao; Liang-Ru Dai; Ming-Hsiang He 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 1 views

4,4Ј-(1,4-Phenylenedioxy)dibenzoic acid as well as the 2-methyl-, 2-tertbutyl-, or 2-phenyl-substituted derivatives of this dicarboxylic acid were synthesized in two main steps from p-fluorobenzonitrile and hydroquinone or its methyl-, tert-butyl-, or phenyl-substituted derivatives. Polyhydrazides a