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Heterochain polymers based on natural amino acids. Synthesis and enzymatic hydrolysis of regular poly(ester amide)s based on bis(L-phenylalanine) α,ω-alkylene diesters and adipic acid

✍ Scribed by Natia Arabuli; George Tsitlanadze; Lamara Edilashvili; Darejan Kharadze; Tsisana Goguadze; Vakhtang Beridze; Zaza Gomurashvili; Ramaz Katsarava

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
455 KB
Volume
195
Category
Article
ISSN
1022-1352

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✦ Synopsis

Abstract

Novel biodegradable regular poly(ester amide)s were synthesized by polycondensation of p‐toluenesulfonic acid salts of bis(phenylalanine) α,ω‐alkylene diesters (1) with bis(p‐nitrophenyl) adipate under mild conditions in organic solvents in the presence of triethyl amine as acid acceptor. Enzymatic hydrolysis (α‐chymotrypsinolysis) of the starting salts 1, the model bis(ester acetamide)s 2 and the obtained poly(ester amide)s 3 was investigated at 37°C and pH 8 using potentiometric titration. It was established that the hydrolysis rate increased with elongation of the α,ω‐alkylene chain. A strong noncovalent immobilization of the enzyme on the polymeric surface was observed.

📜 SIMILAR VOLUMES

Amino acid-based bioanalogous polymers.
Amino acid-based bioanalogous polymers. Synthesis, and study of regular poly(ester amide)s based on bis(α-amino acid) α,ω-alkylene diesters, and aliphatic dicarboxylic acids
✍ R. Katsarava; V. Beridze; N. Arabuli; D. Kharadze; C. C. Chu; C. Y. Won 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 2 views

The purpose of this research was to synthesize new regular poly(ester amide)s (PEAs) consisting of nontoxic building blocks like hydrophobic ␣-amino acids, ␣,-diols, and aliphatic dicarboxylic acids, and to examine the effects of the structure of these building block components on some physico-chemi