Amifostine Protective Effect on Cisplatin-Treated Rat Testis
β Scribed by Leandra Campos Lirdi; Taiza Stumpp; Estela Sasso-Cerri; Sandra Maria Miraglia
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2008
- Tongue
- English
- Weight
- 403 KB
- Volume
- 291
- Category
- Article
- ISSN
- 1932-8486
- DOI
- 10.1002/ar.20693
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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer. High doses of cisplatin have also been known to produce hepatotoxicity. Several studies suggest that supplementation with an antioxidant can influence cisplatin-induced hepatotoxicity. The present study was designed to