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Amide proton transfer imaging of human brain tumors at 3T

✍ Scribed by Craig K. Jones; Michael J. Schlosser; Peter C.M. van Zijl; Martin G. Pomper; Xavier Golay; Jinyuan Zhou

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
597 KB
Volume
56
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water‐exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole‐body clinical scanner and compared with T~1~‐ (T~1~w) and T~2~‐weighted (T~2~w), fluid‐attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT‐weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal‐appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.

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