## Abstract Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of waterβexchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data
Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts
β Scribed by Amandeep Salhotra; Bachchu Lal; John Laterra; Phillip Zhe Sun; Peter C. M. van Zijl; Jinyuan Zhou
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 289 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.1216
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π SIMILAR VOLUMES
## Abstract Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation
## Abstract In this work we demonstrate that specific MR image contrast can be produced in the water signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L gliosarcomas. Although the concentration of these mobile proteins and peptides is only in the millimolar r
## Abstract ## Purpose: To evaluate the capability of amide proton transfer (APT) MR imaging for detection of prostate cancer that typically shows a higher tumor cell proliferation rate and cellular density leading to an MRIβdetectable overall elevated mobile protein level in higher grade tumors.
## Abstract Amide proton transfer (APT) imaging employs the chemical exchange saturation transfer (CEST) mechanism to detect mobile endogenous proteins and peptides. It can be used to detect pH reduction during acute ischemia and thus provide complementary information to perfusionβweighted (PWI) an
## Abstract Amide proton transfer (APT) imaging is a variant form of chemical exchange saturation transfer (CEST) imaging that is based on the magnetization exchange between bulk water and labile endogenous amide protons. Given that chemical exchange is pHβdependent, APT imaging has been shown capa