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Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

✍ Scribed by Jung, Manfred; Brosch, Gerald; Kölle, Doris; Scherf, Hans; Gerhäuser, Clarissa; Loidl, Peter

Book ID
111921734
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
186 KB
Volume
42
Category
Article
ISSN
0022-2623

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec