Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability
✍ Scribed by Eberhardt, Eric S.; Raines, Ronald T.
- Book ID
- 120554860
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 247 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0002-7863
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## Abstract An analytic potential energy function is proposed and applied to evaluate the amide–amide and amide–water hydrogen‐bonding interaction energies in peptides. The parameters in the analytic function are derived from fitting to the potential energy curves of 10 hydrogen‐bonded training dim
Like adding one new hydrogen bond cooperative enhancement stabilizes biological structures. The strength of hydrogen bonding increases with the extent of the H-bonded network. Ab initio calculated binding energies, geometries and spectroscopic properties can be rationalized in terms of non-pairwise-