Cooperative hydrogen bonding in amides and peptides

✍ Scribed by R. Ludwig

• Book ID: 104304074
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 496 KB
• Volume: 84
• Category: Article
• ISSN: 0167-7322
• DOI: 10.1016/s0167-7322(99)00111-7

✦ Synopsis

Like adding one new hydrogen bond cooperative enhancement stabilizes biological structures. The strength of hydrogen bonding increases with the extent of the H-bonded network. Ab initio calculated binding energies, geometries and spectroscopic properties can be rationalized in terms of non-pairwise-additive charge transfer delocalisation between molecular monomers and peptide fragments. This cooperative hydrogen bonding in peptides will be demonstrated for the model compound N-Methylacetamide (NMA) and 310-helical structures (CH3CO-Glyn-NHCH3).