Cooperative hydrogen bonding in amyloid formation
β Scribed by Kiril Tsemekhman; Lukasz Goldschmidt; David Eisenberg; David Baker
- Book ID
- 119824638
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2007
- Tongue
- English
- Weight
- 264 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0961-8368
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π SIMILAR VOLUMES
Like adding one new hydrogen bond cooperative enhancement stabilizes biological structures. The strength of hydrogen bonding increases with the extent of the H-bonded network. Ab initio calculated binding energies, geometries and spectroscopic properties can be rationalized in terms of non-pairwise-
## Abstract Hydrogen bonding in the Ξ±βhelix and Ξ²βsheet has been studied by __ab initio__ molecular orbital calculations carried out on complexes of formamide. Hydrogenβbond geometries were taken from xβray crystallography of polypeptides. Positive cooperativity is found in all cases. The limiting