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Cooperative hydrogen bonding in amyloid formation

✍ Scribed by Kiril Tsemekhman; Lukasz Goldschmidt; David Eisenberg; David Baker


Book ID
119824638
Publisher
Cold Spring Harbor Laboratory Press
Year
2007
Tongue
English
Weight
264 KB
Volume
16
Category
Article
ISSN
0961-8368

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## Abstract Hydrogen bonding in the α‐helix and β‐sheet has been studied by __ab initio__ molecular orbital calculations carried out on complexes of formamide. Hydrogen‐bond geometries were taken from x‐ray crystallography of polypeptides. Positive cooperativity is found in all cases. The limiting