Equilibrium amide hydrogen exchange and protein folding kinetics
β Scribed by Yawen Bai
- Book ID
- 110261904
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 60 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0925-2738
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π SIMILAR VOLUMES
It is shown experimentally that pentafluoroethane undergoes rapid protium-deuterium exchange with water in the presence of hydroxide ion. Addition of dimethylsulfoxide enhances the rate at least by a factor of 100. The first measured fractionation factor data are presented for the temperature range
## Abstract Measurement of the exchange kinetics for amide hydrogens along the protein backbone continues to offer valuable insights into structural stability and conformational dynamics. Since such studies routinely compare samples that differ in solution conditions or mechanical handling, normali