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Ameliorating effect of ursodeoxycholate on the toxic effect of chenodeoxycholate on pancreatic ductal epithelia

✍ Scribed by Katona, Maté; Hegyi, Peter; Rakonczay, Zoltan; Maléth, Jozsef; Rázga, Zsolt; Venglovecz, Viktoria

Book ID
121958611
Publisher
S. Karger AG
Year
2013
Tongue
English
Weight
47 KB
Volume
13
Category
Article
ISSN
1424-3903

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Hepatic bile acid concentrations are elevated in chronic cholestasis because of reduced canalicular excretion and active ileal absorption of the fraction eliminated in the gut. Ursodeoxycholic acid (UDCA) reduces the intestinal absorption of endogenous bile acids, thereby diminishing the concentrati