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Comparative effects of chenodeoxycholic acid and ursodeoxycholic acid on lipid synthesis in rat liver

✍ Scribed by Mingrone, G.; Altomonte, L.; Ghirlanda, G.; Greco, A.V.

Book ID
123000122
Publisher
Elsevier
Year
1981
Tongue
English
Weight
366 KB
Volume
20
Category
Article
ISSN
0232-1513

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Hepatic bile acid concentrations are elevated in chronic cholestasis because of reduced canalicular excretion and active ileal absorption of the fraction eliminated in the gut. Ursodeoxycholic acid (UDCA) reduces the intestinal absorption of endogenous bile acids, thereby diminishing the concentrati