Endogenous bile acids such as chenodeoxycholic acid have been shown to display a suppressive effect in uitro on mononuclear cell activation. We investigated the signal transduction pathway involved in the effect of chenodeoxycholic acid on monocyte procoagulant activity, a model of monocyte activati
Differential effects of chenodeoxycholic and ursodeoxycholic acids on expression of procoagulant activity by human monocytes
β Scribed by Yvon Calmus; Philippe Podevin; Annie Robert; Raoul Poupon
- Book ID
- 118566383
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 585 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0168-8278
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Cell-mediated immunity and macrophage activity, especially that of Kupffer cells, are impaired during cholestasis. Some evidence exists that bile acids play a role in these immune defects. The purpose of this study was to evaluate the effects of individual bile acids on immunity and to determine whe
Hepatic bile acid concentrations are elevated in chronic cholestasis because of reduced canalicular excretion and active ileal absorption of the fraction eliminated in the gut. Ursodeoxycholic acid (UDCA) reduces the intestinal absorption of endogenous bile acids, thereby diminishing the concentrati