Effect of ursodeoxycholic and chenodeoxycholic acid therapy in patients with cholesterol gallstones on intestinal microflora and its bile-acid-metabolizing activity
β Scribed by Annamaria Ferrari; Novella Pacini; Enrica Canzi; Elisabetta Maconi; Annamaria Russo
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 498 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0343-8651
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The objective of this study was to investigate cholesterol metabolism in human gallbladder mucosa, especially in relation to hepatic cholesterol metabolism, gallstone disease and treatment with bile acids. Gallbladder mucosa and liver tissue samples were collected in 44 patients undergoing cholecyst
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250,500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 f 0.8 mole% to 4.4 f 0.2 mole% at 500 mg Urso per day (7.1 mg p
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