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Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

✍ Scribed by John S. K. Kauwe; Jun Wang; Kevin Mayo; John C. Morris; Anne M. Fagan; David M. Holtzman; Alison M. Goate

Publisher
Springer
Year
2008
Tongue
English
Weight
127 KB
Volume
10
Category
Article
ISSN
1364-6745

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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer