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Alternative lengthening of telomeres (ALT) and chromatin: Is there a connection?

✍ Scribed by Thalia Nittis; Lionel Guittat; Sheila A. Stewart

Book ID
116308836
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
422 KB
Volume
90
Category
Article
ISSN
0300-9084

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## Abstract Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In ∼85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are th