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Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular schwannomas

✍ Scribed by R. Thomas; P. D. Antony Herold Prabhu; J. Mathivanan; Rohini; D. Sivakumar; P. N. Jayakumar; B. Indira Devi; S. Satish; K. V. R. Sastry; R. Gope


Book ID
106457606
Publisher
Springer
Year
2005
Tongue
English
Weight
182 KB
Volume
271
Category
Article
ISSN
0300-8177

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## Abstract Tumor‐specific alterations at the __p53__ gene locus in 30 human vestibular schwannomas (VS) comprising 10 confirmed NF2 cases and 20 sporadic cases were analyzed. We found loss of heterozygosity (LOH) at the first intron of the __p53__ gene locus in 54% of the informative cases. This i

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