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Altered properties of erythrocytes in the aged

✍ Scribed by Nechama S. Kosower

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
701 KB
Volume
42
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

Erythrocytes in the aged have a decreased life span. The properties of the red blood cells of old individuals are compared to those of the cells of young individuals. In young individuals, removal of the normal erythrocyte at the end of its lifespan is determined by a signal(s) due to (1) modified phospholipids, (2) modified carbohydrate residues, and/or (3) modified proteins. Similar changes may occur in the erythrocytes of old individuals but at a greater rate. In particular, the enhanced degradation of band 3 protein by calpain may provide a senescence signal. Β© 1993 Wiley‐Liss, Inc.

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