Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma
β Scribed by IH McKillop; CM Schmidt; PA Cahill; JV Sitzmann
- Book ID
- 118686759
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 438 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0270-9139
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Abbreviations: MAPK, mitogen-activated protein kinase; ERK, extracellular signalregulated kinase; HCC, hepatocellular carcinoma; T/N ratio, tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio.
## Abstract ## BACKGROUND The mitogenβactivated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma
Guanine nucleotide regulatory proteins (G-proteins) play an important role in the onset and progression of malignancy. We hypothesized that alterations in inhibitory G-protein (Gi) expression and/or function may contribute to cellular invasion and formation of hepatocellular carcinoma (HCC). H4IIE h