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Altered Disposition and Effect of Lerisetron in Rats with Elevated Alpha1-acid Glycoprotein Levels

โœ Scribed by Nerea Jauregizar; Rosario Calvo; Elena Suarez; Antonio Quintana; Ewa Raczka; John C. Lukas


Book ID
110297283
Publisher
Springer US
Year
2001
Tongue
English
Weight
147 KB
Volume
18
Category
Article
ISSN
0724-8741

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Alpha-1-acid glycoprotein directly affec
โœ Monica Rodriguez; Ignacio Ortega; Itziar Soengas; Nerea Leal; Elena Suarez; Rosa ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 172 KB ๐Ÿ‘ 1 views

Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa