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Effects of alpha-1-acid glycoprotein administration on propranolol binding and beta blockade in rats

โœ Scribed by Daniel E. Keyler; Paul R. Pentel


Book ID
115780969
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
694 KB
Volume
38
Category
Article
ISSN
0006-2952

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Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa